Pharmacokinetics of theophylline and it"s N-7 derivatives in rabbits
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Pharmacokinetics of theophylline and it"s N-7 derivatives in rabbits by Wattanaporn Tavipatana

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Published .
Written in English


  • Theophylline -- Physiological effect.

Book details:

Edition Notes

Statementby Wattanaporn Tavipatana.
The Physical Object
Pagination[22], 171 leaves, bound :
Number of Pages171
ID Numbers
Open LibraryOL14264575M

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Graduation date: Pharmacokinetics of theophylline and N-7 substituted\ud theophylline in rabbits when administered alone and in\ud various combinations were investigated. This thesis has\ud four chapters dealing with etophylline and theophylline;\ud proxyphylline and theophylline; dyphylline and theophylline;\ud and etophylline.   On the contrary, in rabbits with alimentary induced lipid metabolism disturbancest 1/2 of theophylline was practically unchanged and AUC only slightly increased. In conclusion: (1) hyperlipidemia affects the pharmacokinetics of theophylline in human beings, (2) rabbit model with dietetary induced lipid metabolic disturbances is not a suitable Cited by: 6.   Zuidema with others (Ufkes et al., "Efficacy of Theophylline and its NSubstituted Derivatives in Experimentally Induced Bronchial Asthma in the Guinea-Pig", Arch. Int. Pharmacodyn., Vol. , p ()) have also reported that acephylline is ineffective against mediator-induced broncoconstriction in guinea-pigs, and its therapeutic.   Theophylline pharmacokinetic parameters after these treatments are shown in Tables 1 and 2. Theophylline data in 5 of 6 rabbits for Treatment 3 were best described (Table 1) by a two-compartment open model with a mean r^ of h and mean Vd^^ of liter/kg.

AN ABSTRACT OF THE THESIS OF WATTANAPORN TAVIPATANA for the degree of Master of Science in Pharmacy presented on Ap Title: Pharmacokinetics of Theophylline and its N-7 Derivatives in Rabbits. Theophylline is a methylxanthine derivative commonly used in the treatment of small airway disease. It is a bronchodilator, but also increases mucociliary clearance. It is a mild positive inotrope and has mild diuretic properties. The pharmacokinetics of theophylline have been studied in detail in rabbits (May and Jarboe, ). Theophylline (1,3-dimethylxanthine) was incubated with human liver microsomes in the presence of enoxacin, ciprofloxacin, norfloxacin, or ofloxacin. Theophylline, its demethylated metabolites (3-methylxanthine and 1-methylxanthine), and its hydroxylated metabolite (1,3-dimethyluric acid) were measured by high-pressure liquid chromatography, and. Pharmacokinetics of temafloxacin in humans after single oral doses. new quinolonecarboxylic acid derivative, in rabbits, dogs, and humans. Antimicrob Agents Chemother. Jan; 23 (1):1–7. [PMC free article] St-Pierre MV, Spino M, Isles AF, Tesoro A, MacLeod SM. Temporal variation in the disposition of theophylline and its metabolites.

Update on the pharmacokinetics of theophylline Article Literature Review (PDF Available) in Chest 88(2 Suppl)SS September with Reads How we measure 'reads'. from book Theophylline and other Methylxanthines / Theophyllin und andere Methylxanthine: Proceedings of the 4th International Symposium, Frankfurt/M., 29th and 30th May, / Vorträge des 4. The pharmacokinetics and tissue penetration of norfloxacin. J Antimicrob Chemother. Ueda Y, Uchida H, Kusajima H, Irikura T. Mechanism of renal excretion of AM, a new quinolonecarboxylic acid derivative, in rabbits, dogs, and humans. Enoxacin raises plasma theophylline concentrations. Lancet. Jul 14; 2 ()–   The metabolic stability of a compound is determined by its structure. TP, CA and DOXO share identical parental skeleton, and differ only in the N-7 substituent groups. We assigned A, B and C rings to the structures of DOXO to accurately describe the metabolic sites and derivative .