study of vitamin B12 absorption using labelled cobalamins
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study of vitamin B12 absorption using labelled cobalamins by D L. Mollin

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Published by Radiochemical Centre in Amersham .
Written in English


Book details:

Edition Notes

Based on "Vitamin B12 and folic acid absorption and metabolism" in "Radioisotopes in medical diagnosis" edited by H. Vetter and E.H. Belcher, published by Butterworths.

Statement[by] D.L. Mollin [and] A.H. Waters.
SeriesMedical monographs -- 6.
ContributionsWaters, A H.
The Physical Object
Pagination24p.
Number of Pages24
ID Numbers
Open LibraryOL20704646M

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The absorption test described uses carbonlabeled vitamin B 12 (14C-B 12) coupled to sensitive detection of the 12 by accelerator mass spectrometry (AMS). AMS was originally developed for carbon dating in archaeological or earth science samples; however, in the past decade or so, its sensitivity has been exploited for tracing of biological systems (6).Cited by: Vitamin B12 (cobalamin) deficiency may be caused by inadequate dietary intake of B12 or by conditions that result in malabsorption of the vitamin. Crystalline vitamin B12, usually in the form of cyanocobalamin, is administered parenterally (ie, intramuscularly) or orally for treating deficiency by:   1. The efficiency of production and utilization of vitamin B 12 was studied with sheep given a cobalt-deficient diet with and without supplementary Co (1 mg/d). Vitamin B 12 to lignin ratios in rumen contents were used to estimate minimum rates of production and these were related to faecal and urinary excretion. Tissue distribution and excretion of vitamin B 12 were Cited by:   Our study shows that as little as µg is enough to correct cobalamin deficiency. All our subjects had a very low serum cobalamin concentration at entry to the study (mean pmol l −1) and all were in a preclinical state of cobalamin deficiency. None had specific symptoms of cobalamin deficiency or by:

Vitamin B12 is a water-soluble vitamin. It is one of the eight vitamins of vitamin B complex, needed for blood and cell maturation. It helps maintain healthy nerve cells and red blood cells, and it is needed in DNA replication. Its deficiency may .   Vitamin B12 plays a vital role in many bodily systems, such as the production of cellular energy and DNA synthesis. A range of factors can influence absorption rates of B12, which can result in the development of B12 deficiency. To address this, individuals can take a range of supplements such as oral B12 sprays. Cobalamin. Vitamin B12 Absorption. Understanding vitamin B12 absorption can help with understanding causes of vitamin B12 deficiency. (1) Dietary vitamin B12 is normally bound to proteins in food and is provided by food products of animal origin. (2) Pepsin and acid pH in the stomach will degrade these food proteins and release vitamin B Vitamin B12 (B12; also known as cobalamin) is a B vitamin that has an important role in cellular metabolism, especially in DNA synthesis, methylation and mitochondrial metabolism. Clinical B12 deficiency with classic haematological and neurological manifestations is relatively uncommon.

5 Dong Jiang, Newcastle University, PhD Thesis, Mammals are not able to synthesis cobalamins, so they must be supplied from the diet. B 12 can be found primarily in meat, fish, eggs and dairy products. The daily requirement of vitamin B 12 for the human body is low g. 7 Consequently, there is an elaborate mechanism for absorption, blood transportation and . essential for normal absorption of vitamin B12, as malabsorption of the vitamin has been described in association with congenital deficiency of trans-cobalamin II.`, An enterohepatic circulation of vitamin B12 has been suggested because the amount of vitamin B12 excretedin thebile is muchhigherthanthat excreted in the urine andthe by: Vitamin B12 absorption: Relationship between oral administration and urinary excretion of cobaltlabeled cyanocobalamin following a parenteral by: Vitamin B12 is a water-soluble vitamin and an important micronutrient with critical role in DNA, protein, and lipid synthesis. It is responsible for one-carbon metabolism and cell division of nervous and hematopoietic cells. Among its various functions, the role as immunomodulator in cellular immunity, especially in elevating the number of CD8+ cells and NK cells, attracts Author: Tatina T. Todorova, Neli Ermenlieva, Gabriela Tsankova.